0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

STUDIES ON LIVE POLIOVIRUS VACCINE:  ITS NEUROTROPIC ACTIVITY IN MONKEYS AND ITS INCREASED NEUROVIRULENCE AFTER MULTIPLICATION IN VACCINATED CHILDREN

Joseph L. Melnick, Ph.D.; Matilda Benyesh-Melnick, M.D.; James C. Brennan, M.D.
JAMA. 1959;171(9):1165-1172. doi:10.1001/jama.1959.03010270001001.
Text Size: A A A
Published online

Comparative tests of the monkey neurovirulence of the Lederle-Cox and the Sabin strains of poliovirus, which are candidates for an orally administered vaccine, have indicated that children have been fed poliovirus strains possessing greater neurotropic activity than had been suspected. There was also evidence that, in passing through human hosts, some of the vaccine strains underwent genetic changes with respect to at least two properties in tissue culture, namely, the capacity to grow at 40 C (T marker) and the capacity to grow at low bicarbonate concentration (d marker). These changes after human passage were associated with increases in monkey neurovirulence. A further study of 596 postvaccination fecal specimens revealed that marked, though not complete, interference occurred between the vaccine virus and the enteroviruses already circulating in the population. This interference affected adversely the formation of the desired antibodies. It has not been proved that the strains used as orally given vaccine are dangerous either for the vaccinated child or for the community, but caution is called for, especially in view of the genetic instability of the attenuated strains of poliovirus currently available.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();