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September 26, 1959, Vol 171, No. 4 >

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ARTICLE | September 26, 1959

TREATMENT OF HYPSARHYTHMIA WITH ACTH

Fred W. Stamps, M.D.; Erna L. Gibbs; Ira M. Rosenthal, M.D.; Frederic A. Gibbs, M.D.
JAMA. 1959;171(4):408-411. doi:10.1001/jama.1959.03010220032009.
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Hypsarhythmia is a type of epilepsy which has, in the past, had an extremely poor prognosis. Eleven per cent of the patients died before the third year of life, and 87% of those who lived were feeble-minded. The present series of 60 children were treated with corticotropin for one year, with marked improvement in 36 and almost complete relief in 5 as judged by electroencephalographic criteria and subjective symptoms. The mode of action of the drug was not explained, and its effectiveness in the individual case could not be predicted from a knowledge of the etiology. By contrast with the poor results obtained in the past, these recent results with corticotropin are encouraging.

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AAM 2010;304:1493-1495.
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BMJ 2010;341:c5893-c1494.
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