To the Editor:—
The report by Lattimer and coworkers (The Journal, June 20, p. 938) on the serious problem of urinary infections due to resistant strains of Aerobacter aerogenes merits attention. In considering the use of kanamycin as a preferred method of therapy in such infections, one must bear in mind the reports of impaired hearing that have been attributed to kanamycin (Lustberg, A., and Hamburger, M., J. A. M. A.170:806 [June 13] 1959; Naunton, R. F., and Ward, P. H.; A. M. A. Arch. Otolaryng.69:398 [April] 1959; and Damuth, H., personal communication).It therefore seems appropriate to direct the attention of the readers of The Journal to the study by Hughes and co-workers (J. Urol.80:75 [July] 1958) in which cycloserine appeared to be "of value in the management of chronic urinary tract infection on an outpatient basis, particularly those infections due to A.