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August 15, 1959, Vol 170, No. 16 >
ARTICLE | August 15, 1959

CONTROL OF TETANUS SPASMS BY ADMINISTRATION OF MEPROBAMATE

Meyer A. Perlstein, M.D.
JAMA. 1959;170(16):1902-1908. doi:10.1001/jama.1959.03010160018006.
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The course of tetanus has been studied in 39 patients treated with meprobamate. Among the 20 who were addicts to heroin (diacetylmorphine) there were 14 deaths; of the 19 nonaddicts only 4 died. Morbidity has been greatly reduced. Before the introduction of the meprobamate treatment, in a group of 51 patients there had been 33 deaths, 26 being among the 36 heroin addicts in the group. While the mortality among the heroin addicts remained the same, mortality among the nonaddicts was strikingly reduced by the use of meprobamate. In most patients, complete control of somatically induced seizures was attained by giving 400 mg. of meprobamate in 5 cc. of polyethylene glycol intramuscularly every four hours. Two case histories illustrate its effects, which are manifest within 15 minutes and last three or four hours after each injection.

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