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Charles A. Beck, M.D.; Irving J. Shapiro, M.D.
JAMA. 1959;170(10):1175-1176. doi:10.1001/jama.1959.63010100001012.
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The behavior pattern of adenocarcinoma (hypernephroid carcinoma) is often bizarre.1 It is not unusual for the tumor to become manifest by virtue of metastatic spread with the original lesion quiescent. We have seen two patients in whom biopsy of a bone tumor showed presence of adenocarcinoma, with the original lesion so small that it could not be revealed by intravenous or retrograde pyelography. Cases have been reported in which a solitary nodule appeared in the lung2 and the disease was arrested for years by the removal of the original lesion and the metastasic growth. Within the past few years we have removed a carcinoma of the kidney with multiple metastases in the lungs and one tibia. Aided by roentgenologic therapy to the bone, there has been partial regression of the metastases, enabling the patient to walk with the aid of a cane and to resume a gainful occupation. The disease seems to have become quiescent. The case reported on here we believe worthy of attention because of an extremely long period of survival in the presence of known


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