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May 16, 1959, Vol 170, No. 3 >
ARTICLE | May 16, 1959

EFFECT OF A PRACTICAL DIETARY REGIMEN ON SERUM CHOLESTEROL LEVEL

Philip A. Boyer, M.D.; James T. Lowe, Ph.D.; Robert W. Gardier, Ph.D.; John D. Ralston, M.D.
JAMA. 1959;170(3):257-261. doi:10.1001/jama.1959.03010030001001.
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The fact that experimentally produced atheromatous plaques are reversible lesions suggests the possibility of benefit from diets tending to lower the blood cholesterol levels. The effects of a diet of this sort were studied in 300 institutionalized patients under conditions permitting rigorous control. The significant feature was the use of a margarine containing 64.2% of nonhydrogenated corn oil. The kitchen staff prepared the same dishes as before with few modifications, and the transitions from contratest to test diet went unnoticed by the majority of patients and by many members of the staff. In a nine-month study it was shown that this dietary alteration raised the percentage of linoleic acid in the diet about 300% and significantly reduced the blood cholesterol levels in a manner acceptable both to the patients and to the staff.

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