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May 9, 1959, Vol 170, No. 2 >
ARTICLE | May 9, 1959

EFFECT OF ISONIAZID IN ANGINA PECTORIS

Elmer Pader, M.D.; Hyman Levy, M.D.
JAMA. 1959;170(2):157-159. doi:10.1001/jama.1959.03010020015004.
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Isoniazid was administered over periods of three weeks to 20 patients who had been known to have angina pectoris for at least a year. The dosage was 300 mg. a day in three divided doses of 100 mg. each. The patients were instructed to continue taking nitroglycerin as needed, but all other coronary vasodilators were withdrawn. Ten patients completed the three-week course without decreased anginal pain or increased capacity for effort. Eight others did not complete the course, either because of disabling side-effects or because they saw no improvement. Only two patients felt better, and only one of these noted any return to his pretreatment state when he stopped taking the isoniazid. The dosage used in this series of patients, while sufficient to cause disturbing side-effects, appeared to have little value in the treatment of the anginal syndrome.

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