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April 25, 1959, Vol 169, No. 17 >
ARTICLE | April 25, 1959

CLONIC CONVULSIONS

Sidney Cohen, M.D.
JAMA. 1959;169(17):2066. doi:10.1001/jama.1959.03000340098027.
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ABSTRACT

To the Editor:—  In the case report on "Clonic Convulsions After the Oral Use of Perphenazine (Trilafon)" in The Journal (169:834-835 [Feb. 21] 1959), the authors suggest that the patient had an epileptiform seizure. From the case summary it is noted that jaw and neck tremors were observed first, followed by generalized, clonic convulsions without loss of consciousness, opisthotonus, and rolling of the eyes upward. This description is reminiscent of the group of dyskinetic reactions of the extrapyramidal syndrome. Coming on shortly after the administration of perphenazine and characterized by tremors of the head and neck, hyperextension of the trunk, oculogyric crises, and generalized muscle spasms, it seems to be a striopallidal disorder rather than epilepsy.These bizarre and sometimes frightening myoneural disturbances occasionally occur after the use of even small amounts of phenothiazines with a piperazine ring in the side chain and have been mistaken for epilepsy, encephalitis,

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