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April 18, 1959, Vol 169, No. 16 >
ARTICLE | April 18, 1959

SKIN TESTING

JAMA. 1959;169(16):1880. doi:10.1001/jama.1959.03000330052010.
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All physicians who perform scratch or intradermal tests with allergenic extracts, and all those who have become skeptical of the value of such tests, will be interested in a recent basic study in this field by Perlman.1 This investigator obtained allergenic extracts for routine skin testing from five commercial laboratories distributed throughout the United States and from two allergy clinics. These presumably equivalent extracts were then assayed biologically in patients with hay fever or asthma. Extracts of a given allergen from each of the seven sources were applied simultaneously by the scratch method to the skin of a patient known to be hypersensitive to that allergen. Reactions varied from strongly positive to negative in the same patient, and many of the extracts were found to be biologically inert in the concentrations supplied. This was in spite of the fact that most of the extracts had been standardized as to

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