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ARTICLE | April 4, 1959

THE NEPHROTIC SYNDROME

Robert M. Kark, M.D.; Conrad L. Pirani, M.D.; Victor Pollak, M.B.

JAMA. 1959;169(14):1657. doi:10.1001/jama.1959.03000310109025.

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To the Editor:— The editorial on the nephrotic syndrome in The Journal ( 169:846 [Feb. 21] 1959) disturbs us since we are sure it will confuse many readers. It quotes two references by ourselves and our co-workers which deal with the nephrotic syndrome. The other reference is a paper by Hodges (J. M. Soc. New Jersey54:11 [Jan.] 1957) which deals with the lower nephron syndrome—so-called lower nephron nephrosis or acute tubular necrosis. Since there is no clinical and pathological similarity between these two conditions, and treatment is completely different, the editorial is confusing and misleading. In discussing the nephrotic syndrome, the editorial states that "pathologically the characteristic lesion is necrosis of the tubules." This lesion is seen in lower nephron nephrosis but not in the nephrotic syndrome. There are no characteristic histological lesions in the kidneys of patients with nephrotic syndrome. This condition has many causes and many

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Kark RM, Pirani CL, Pollak V. THE NEPHROTIC SYNDROME. JAMA. 1959;169(14):1657. doi:10.1001/jama.1959.03000310109025.

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