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March 21, 1959, Vol 169, No. 12 >
ARTICLE | March 21, 1959

SIMPLIFIED SCREENING TEST FOR CYSTIC FIBROSIS OF THE PANCREAS

Edwin M. Knights, M.D.; James S. Brush, Ph.D.; John Schroeder
JAMA. 1959;169(12):1279-1280. doi:10.1001/jama.1959.03000290005002.
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A test paper has been devised for use in quick examination of large numbers of people to detect increased concentrations of chloride in the sweat. The paper is impregnated with silver chromate, which is red. Upon contact with a solution of sodium chloride the red color is replaced by the white color of silver chloride. The paper was found easy to prepare, store, and apply, and after use it could be kept with the records of the case. Used in 91 healthy subjects and 9 patients known to have cystic fibrosis of the pancreas, it gave 3+ reactions with all the latter group. False-positive results were obtained in some children with fever or under emotional stress. Relatively strong (2+) reactions were obtained in some parents of children with cystic fibrosis, which is known to be inheritable.

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AAM 2010;304:1493-1495.
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BMJ 2010;341:c5893-c1494.
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