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William M. S. Ironside, M.D.; James W. J. Carpender, M.D.; Robert Roedal, M.D.; John R. Lindsay, M.D.
JAMA. 1959;169(8):783-786. doi:10.1001/jama.1959.03000250001001.
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Factors that might affect the prognosis in carcinoma of the larynx have been studied in 93 patients treated not less than five years ago. The patients were classified with respect to both the stage of the disease and the location of the lesion. These factors to some extent influenced the choice of treatment, which was either by surgery or by radiation. (Supervoltage was not used in this series.) Comparisons were therefore difficult. In 65 of the 93 cases the lesion was at the glottis, and 37 of the 65 glottic lesions were classified as stage 2 (carcinoma infiltrating but not extending beyond larynx, mobility of larynx impaired or lost, no nodes palpable). Of the 37, 25 (68%) survived five years or more. On the basis of experience with glottic lesions in stage 1 and early stage 2 it is concluded that this group may safely be treated primarily by external radiation, provided that a careful follow-up can be assured.


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