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February 7, 1959, Vol 169, No. 6 >
ARTICLE | February 7, 1959

IPRONIAZID THERAPY OF PSORIASIS

Victor H. Witten, M.D.; Marion B. Sulzberger, M.D.; Cyril March, M.D.; William Dvorine, M.D.
JAMA. 1959;169(6):591-593. doi:10.1001/jama.1959.73000230001011.
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This short report summarizes our experience with iproniazid (Marsilid) in the treatment of psoriasis vulgaris. The stimulus to this study came from the publications of Morin and Pult,1 who reported the beneficial effect of iproniazid therapy in 4 patients with psoriasis, and of Sapuppo,2 who confirmed this effect in 10 additional patients.

Our interest in this form of therapy was some-what reinforced by the fact that some physicians and patients connect exacerbations of psoriasis with psychic and emotional changes and that iproniazid has been reputed to be a psychic energizer or stimulant (antidepressive),3 which would elevate mood, as well as a tranquilizer or psychotomimetic drug in certain patients.3b Because some of our patients with psoriasis also suffered from mood swings and periods of depression, whenever we prescribed iproniazid we made it our objective to observe its effects on the psyche as well as on the skin.

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