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ASSOCIATION OF HEMADSORPTION VIRUSES WITH RESPIRATORY ILLNESS IN CHILDHOOD

Robert M. Chanock, M.D.; Andrew Vargosko, Ph.D.; Alia Luckey, M.S.; M. Katherine Cook, Ph.D.; Albert Z. Kapikian, M.D.; Thomas Reichelderfer, M.D., M.P.H.; Robert H. Parrott, M.D.
JAMA. 1959;169(6):548-553. doi:10.1001/jama.1959.03000230004002.
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Hemadsorption, a specific phenomenon dependent on the hemagglutinating property of the virus, was observed in two viruses newly recovered from children with acute respiratory disease. In a study involving 1,738 children in three hospitals, one or the other of the two hemadsorption viruses was recovered from 54 (6%) of 859 patients with respiratory disease. It appeared that the two viruses were capable of causing a wide variety of clinical manifestations, including croup, pneumonia, bronchiolitis, pharyngitis, and mild afebrile disease. Serologic studies suggested that approximately 20% of the respiratory illness severe enough to require hospitalization in the Washington, D. C., area in 1957-1958 was associated with hemadsorption virus infection.

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