0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

HAZARDS OF ANTIBIOTIC THERAPY

Wallace E. Herrell, M.D.
JAMA. 1958;168(14):1875-1879. doi:10.1001/jama.1958.03000140037010.
Text Size: A A A
Published online

The indiscriminate use of antibiotics has created serious problems. Two episodes here given illustrate the misuse of penicillin. Patients for whom it is ordered should be questioned as to evidence of sensitivity, and after an injection they should be watched by a physician or nurse for 30 minutes. Reactions, if they occur, should be treated not with oxygen but with epinephrine or with steroids intravenously. The use of streptomycin is rarely followed by major complications, but its minor side-effects include contact dermatitis, and its toxic effects on the eighth cranial nerve, though not life-endangering, are distressing. Preliminary studies indicate that dihydrodesoxystreptomycin is less toxic. The fact that the tetracyclines are highly effective and can be given by mouth has resulted in widespread misuse. They can cause blood dyscrasia and anaphylactic reactions, but the most serious major hazard is superimposed staphylococcic enterocolitis and wound infections. There is a definite association between chloramphenicol and aplastic anemia. The rational use of antibiotics in the future depends on a return to strict aseptic technique in hospitals. The occasional temporary exclusion of one or more antibiotics from the hospital, long enough for the common pathogens to regain their sensitivity to it, would greatly improve the effectiveness and increase the safety of antibiotic medication.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();