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Jethro B. Rochelle III, M.D.; Allen C. Bullock, M.D.; Ralph V. Ford, M.D.
JAMA. 1958;168(4):410. doi:10.1001/jama.1958.63000040002010a.
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Although chlorothiazide (Diuril) was initially introduced as an orally given diuretic,1 subsequent clinical trial readily revealed this agent to possess significant antihypertensive properties. In 25 patients moderate hypertension hadbeen somewhat less than adequately controlled for a period of at least six months with Rauwolfia (Raudixin) alone. In another 25 patients it had been inadequately controlled for a similar period with a regimen of Rauwolfia and mecamylamine (Inversine). Chlorothiazide (500 mg. after breakfast and lunch) was added to the therapeutic regimen of each patient.

In the first group of patients, the upright mean blood pressure was reduced from the control level of 131 mm. Hg to 109 mm. Hg (p<0.01) after 12 weeks of chlorothiazide therapy. A contemporary decrease in body weight became significant at the end of 12 weeks (table 1). In the group of patients receiving a drug combination of Rauwolfia and mecamylamine, the mean blood pressure in


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