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CEREBROSPINAL FLUID PROTEIN AND GLYCOPROTEIN LEVELS IN CONGESTIVE HEART FAILURE

Joseph B. Green, M.D.; Francis M. Forster, M.D.; Walter C. Hess, Ph.D.; Nezahat F. Henderson, M.S.
JAMA. 1958;167(12):1494-1495. doi:10.1001/jama.1958.72990290012009d.
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Apostol and associates1 reported that the glycoprotein concentration in the cerebrospinal fluid (CSF) was frequently increased in neurological diseases; the level was especially high in patients with brain tumors. It was shown by Roboz and co-workers2 that the serum glycoprotein content is also increased in cases of central nervous system neoplasms. Other workers have indicated that diabetes,3 myocardial infarction,4 and rheumatic diseases5 may be associated with an increase in the serum carbohydrates which are bound to protein. In addition, this serum change has been observed in patients with congestive heart failure.6 It seemed pertinent to determine if the glycoprotein content of the cerebrospinal fluid, as well as of the serum, was increased in a common systemic disease, such as congestive heart failure. Such information would be of importance in assessing the specificity of elevations of the CSF glycoprotein level for lesions of the nervous

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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