The 35 participants of this conference on shock and circulatory homeostasis included internists, surgeons, physiologists, pharmacologists, and biologists. The conference dealt primarily with the following subjects: experimental shock in relation to hepatic blood flow, bacteria, protection by chlortetracycline, germ-free rats, adrenergic, cholinergic, and ganglionic blocking agents, humoral factors, hepatic ferritin systems, hypothermia and chlorpromazine, and lymphatic adjustments. This book enables a large audience to share in the findings of this as in previous Macy conferences. The recording of the informal discussions gives the reader a sense of having been present at the conference. Particularly worthy examples of this are the discussions of criteria of tissue anoxia (p. 21) and of health (pp. 141-144). This should be read by all investigators interested in experimental shock and related phenomena. It is also recommended to those clinicians who enjoy periodic forays into the frontiers of biological and medical knowledge.