We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......


Calvin W. Woodruff
JAMA. 1958;167(6):715-720. doi:10.1001/jama.1958.02990230041008.
Text Size: A A A
Published online


The possible causes of hypochromic anemia were sought in a study of 272 infants whose blood had been found to contain less than 9 Gm. of hemoglobin per 100 cc. The most common factor was prematurity or a birth weight of less than 3,000 Gm. Prematurity was present in 80% of the patients with a hemoglobin concentration of less than 5 Gm. per 100 cc. The incidence of severe hypochromic anemia in infants weighing more than 4,000 Gm. is extremely low. A first child was less liable to become anemic than were later siblings; single children were less liable than twins; and girls less liable than boys. Dietary information was incomplete, but the most frequent dietary pattern, before treatment, was found to have been two quarts of milk daily, supplemented with mashed potatoes, dried beans, crackers, or bread. The evidence showed, however, that deficient iron intake was not the sole cause of severe hypochromic anemias. Prevention therefore depends largely on the recognition of susceptible infants in the population. These should be watched carefully and treated prophylactically with adequate doses of medicinal iron.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.