Louis Tuft, M.D.; Donald D. Neish Jr., B.S.
JAMA. 1958;167(1):60-62. doi:10.1001/jama.1958.72990180003015a.
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During the past four years, various members of the staff of the Allergy Clinic at Temple University Hospital have been investigating the value and possible usefulness of eye tests with inhalant allergens in the diagnosis of allergic conditions. During the course of these studies, an opportunity was afforded us to compare the effect of different ophthalmic solutions, or decongestants, which are used for instillation into the conjunctival sac in patients with allergic reactions affecting this membrane. It is the purpose of the present paper to report the significant findings of this study.

Introduction of a specific allergen into a sensitized conjunctival sac in the performance of ophthalmic or eye tests produces a positive reaction with the following signs: hyperemia, lacrimation, and chemosis. The patient complains of varying degrees of itching or similar discomfort. When the patient is markedly allergic to the test substance, the reaction is rapid in onset, extensive,


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