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Joseph A. Bell, M.D., Dr. P.H.; Thomas G. Ward, M.D., Dr. P.H.; Albert Z. Kapikian, M.D.; Alexis Shelokov, M.D.; Thomas E. Reichelderfer, M.D., M.P.H.; Robert J. Huebner, M.D.
JAMA. 1957;165(11):1366-1373. doi:10.1001/jama.1957.02980290006002.
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Fever, chills, and other symptoms characteristic of influenza appeared in 18 out of 23 (78%) unvaccinated volunteers about 38 hours after the nasopharynx was sprayed with nasopharyngeal secretions containing living virus from three influenza patients. The virus was influenza A/Valley Forge/57, which was antigenically similar to the Far East strain. When the same material was administered to 32 volunteers who had been vaccinated against influenza A/Japan/305/ 57, the cases of febrile illness numbered 14 (44%). The vaccination and the challenge inoculation both induced a hemagglutination inhibition antibody response. Influenza virus was recovered from 14 (41%) of ill volunteers. The vaccination therefore gave significant though incomplete protection against Asian influenza.


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