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Samuel S. Binder, M.D.; Willard Steele Sr., M.D.
JAMA. 1957;165(2):154-155. doi:10.1001/jama.1957.72980200006009c.
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Acetazolamide (Diamox) has become a popular drug in the practice of obstetrics and gynecology. Its value in the treatment of premenstrual tension has been described by Greenblatt.1 Assali and co-workers2 have also mentioned its action in treating edema of pregnancy. In other branches of medicine, acetazolamide has been used for the treatment of congestive heart failure,3 glaucoma,4 and epilepsy.5

The toxicity and side-reactions described have been minimal and in our experience have consisted mainly of tingling sensations in the fingers and occasional drowsiness. We have observed an unusual side-reaction that was quite alarming to the patient and somewhat baffling to the physicians. This consisted of an acute transitory myopia. One other such case has been reported by Black.6

Report of a Case  The patient was a 30-year-old woman, seen for the first time on Aug. 21, 1956, with the complaints of severe abdominal swelling,


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