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ARTICLE |

SERUM LACTIC DEHYDROGENASE—A DIAGNOSTIC AID IN MYOCARDIAL INFARCTION

Roderick P. MacDonald, Ph.D.; John R. Simpson, M.D.; Egon Nossal, B.S.
JAMA. 1957;165(1):35-40. doi:10.1001/jama.1957.02980190037009.
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The usefulness of specific enzyme reactions to clinical medicine is becoming increasingly more apparent. Patients suffering destruction of various tissue cells have increased enzymatic activity in their serum. The enzymes normally present within the cells are liberated into the blood stream as cell destruction occurs. The determination of serum lactic dehydrogenase (LDH) as an aid in the diagnosis of acute myocardial infarction has two advantages: first the increased elevation is present for as long as six to eight days after attack; second, the technical procedure is far less complicated than other enzyme tests. LDH determination, not ordinarily necessary in the diagnosis of acute myocardial infarction, is particularly helpful when the electrocardiograph pattern masks the recent changes of an acute infarction.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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