We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |


Norman O. Rothermich, M.D.; Vol K. Philips, M.D.
JAMA. 1957;164(18):1999-2004. doi:10.1001/jama.1957.02980180001001.
Text Size: A A A
Published online


• A new test, involving the use of a suspension of latex particles, was applied to 1,606 samples of serum from 907 patients whose clinical diagnoses, whether of rheumatic disease or otherwise, had been established. The latex particles in stock suspension had a fairly uniform mean diameter of 1.17 microns. For the test they were mixed with borate buffer and gamma globulin. When the serum to be tested is added to this mixture it may or may not cause aggregation of the particles. A positive test is indicated by discernible aggregation, which can be read with the naked eye. Of 291 patients who met the clinical criteria for the diagnosis of rheumatoid arthritis, 245 (84.2%) showed positive latex fixation tests; the 46 instances of false-negative reactions have been studied. Of 414 patients with rheumatic disease other than rheumatoid arthritis, 399 (96.3%) gave negative latex fixation reactions; the 15 false-positive reactions have likewise been studied. The test was as reliable as are the various sheep cell agglutination tests now used for serologic detection of rheumatoid arthritis, and it had the advantage of being simple, very inexpensive, fast, and clinically useful.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.