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Robert E. Olson, M.D., Ph.D.
JAMA. 1957;164(16):1758-1765. doi:10.1001/jama.1957.62980160005009.
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Despite the large volume of research that has been published in the field of endocrinology during the past 50 years, the precise biochemical function of a hormone has yet to be established. It is clear, however, that several hormones influence protein metabolism in such a way as to produce effects of considerable interest to the clinician as well as to the biochemist. The purpose of this presentation will be to consider both the clinical and biochemical implications of the hormonal adjustments in a number of common medical situations.

The object of endocrine control might be stated to be an adjustment of metabolism through the intervention of numerous hormones acting in specific biochemical or biophysical areas to produce optimum substrate concentrations, adequate enzyme activity, and appropriate work performance in all organs and tissues in a variety of physiological and pathological states. In some instances, two hormones may stimulate a single process


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