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TREATMENT OF ENTEROBIASIS WITH ONE ORAL DOSE OF PROMETHAZINE HYDROCHLORIDE

Thomas S. Bumbalo, M.D.; Lois J. Plummer, M.D.; John R. Warner, M.D.
JAMA. 1957;164(15):1651-1653. doi:10.1001/jama.1957.02980150019006.
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• One hundred seven children infected with Enterobius vermicularis were treated with 125 mg. of promethazine given in a single dose at bedtime. Adhesive cellophane tape smears were made in establishing the diagnosis and following the course of treatment; eggs present on the skin about the anus adhere to the tape and are thus transferred to glass slides for identification. Beginning 10 days after treatment, one cellophane tape smear was taken daily for seven days. Only 5 of the 107 children gave consistently negative results through the sevenday period; the percentage of successes was therefore 5.3%. A second series of 24 patients were treated with 125-mg. doses of pyrathiazine. The percentage of successes was 12.5%. That these dosages were not far from the limits of tolerance was shown by the appearance of nausea, disorientation at night, and enuresis in some of the children, although in general the drugs were tolerated well. Since it must be assumed that the incidence of side-effects would be increased by any increase in dosage of either of these two drugs, the authors recommend that other, more effective oxyuricides of established value be used instead.

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