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METHALLENESTRIL, A NEW SYNTHETIC ESTROGEN

Norman G. Schneeberg, M.D.; Leon Perczek, M.D.; John H. Nodine, M.D.; William H. Perloff, M.D.
JAMA. 1956;161(11):1062-1067. doi:10.1001/jama.1956.02970110028009.
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• Methallenestril was administered to 52 women with complaints referred to the menopause and was effective in 50. The optimum dosage for ameliorating the hot flushes was 10 mg. daily by mouth. No significant untoward effects were observed.

Postpartum breast engorgement, pain, and lactation were treated in 198 patients by methallenestril given in doses of 15 to 50 mg. daily by mouth. The 15 mg. dosage inhibited lactation in 24 of one group of 31 patients, and higher dosages did not appear to have any advantages; comparisons among groups of patients receiving methallenestril, diethylstilbestrol, and a placebo made it doubtful whether either drug was effective in suppressing postpartum breast disorders.

Determinations of the amount of gonadotropin in the urine showed that methallenestril markedly reduces the rate of excretion of this substance. A dosage of 18 to 20 mg. per day was required to give a significant reduction.

Observations in these and other patients to a total of 270 showed that methallenestril can be recommended as an estrogenic substance for routine clinical use.

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