Meyer A. Perlstein, M.D.
JAMA. 1956;161(11):1040-1044. doi:10.1001/jama.1956.02970110006003.
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• Meprobamate, which gives muscular relaxation without significant effects on circulation and respiration, was administered by mouth to 130 patients with various nervous disorders characterized by seizures, hyperactivity, or tension form of cerebral palsy. The most convincing relief of symptoms was found in 18 patients with idiopathic petit mal, where 15 were helped significantly and none were made worse. The drug was much less effective in idiopathic grand mal; in fact, 3 out of 14 patients with grand mal were made worse. The drug was also of some value in decreasing the tension of patients with athetosis and with some behavior disturbances. The dosage was 100 to 800 mg., generally given two to four times a day, and this was increased until either clinical benefit or drowsiness resulted. The time of effective action was about four hours. The dosage used in this study did not cause any toxic side-effects.


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