Ernest Witebsky, M.D.; Noel R. Rose, Ph.D.; Kornel Terplan, M.D.; John R. Paine, M.D., Ph.D.; Richard W. Egan, M.D.
JAMA. 1957;164(13):1439-1447. doi:10.1001/jama.1957.02980130015004.
Text Size: A A A
Published online

• An explanation of chronic thyroiditis in man was sought in observations made on rabbits, dogs, guinea pigs, and human subjects. The rabbits received injections of saline extracts of rabbit thyroid glands. The tests for circulating autoantibodies utilized the phenomena of precipitation, complement fixation, and tanned-cell hemagglutination. The third of these, based upon the principle of altering the surface of the red blood cells by dilute tannic acid so that they absorb proteins, was particularly sensitive. The three tests were applied to serums from 35 rabbits injected with rabbit thyroid extract, and thyroid autoantibodies were found in 32. Structural damage was found in the thyroid roughly in proportion to the autoantibody titer in the serum. Similar studies were carried out in dogs and guinea pigs with canine and guinea pig thyroid extracts respectively. The three tests were then applied to serums from patients with chronic thyroiditis. Twelve such patients were found whose serums contained circulating antibodies specifically directed against extracts of human thyroid glands. Three typical case histories are given, with histological findings on thyroid tissue removed during surgery. Six other patients with chronic thyroiditis, proved histologically, were not found to have autoantibodies in their serums at the time of study. These findings lead to the hypotheses that some types of chronic thyroiditis are related to an autoimmunization process within the patient against his own thyroid tissue, and that thyroid autoantibodies are at once indicators and links in the chain of pathological processes.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.