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Carl F. Essig, M.D.; John D. Ainslie, M.D.
JAMA. 1957;164(12):1382. doi:10.1001/jama.1957.02980120086019.
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To the Editor:—  Evidence is steadily accumulating that abrupt withdrawal of meprobamate from patients who have been ingesting this drug in large amounts may be followed by major convulsions. Barsa and Kline (Am. J. Psychiat.112:1023 [June] 1956) observed single convulsions in 6 to 25 schizophrenics who had received 2.4 Gm. of meprobamate daily for six months; Lemere (J. A. M. A.160:1431 [April 21] 1956 and A. M. A. Arch. Neurol. & Psychiat. 76:205 [Aug.] 1956) noted a seizure in one patient who had taken 6.4 Gm. of meprobamate daily for a month; and Tucker and Wilensky (Am. J. Psychiat. 113:698 [Feb.] 1957) reported convulsions in 2 of 32 psychotic patients who had received 1,600 mg. of meprobamate, increasing to 4,800 mg. daily, for three months. Both Lemere, and Tucker and Wilensky, also remarked on postwithdrawal anxiety and tension in a significant percentage of cases.


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