0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

EARLY USE OF ANTICOAGULANTS IN TREATMENT OF MYOCARDIAL INFARCTION

Irving S. Wright, M.D.
JAMA. 1957;163(11):918-921. doi:10.1001/jama.1957.02970460008003.
Text Size: A A A
Published online

• Series of patients with myocardial infarction treated with anticoagulants have generally shown a decrease in death rate of one-third to one-half that seen in series of such patients on other types of treatment. The incidence of thromboembolic complications has been more strikingly reduced. Contraindications and caution must be observed with anticoagulant therapy is used, and laboratory facilities must be adequate to measure its effect on the blood. For rapid action, 1,200 to 1,500 mg. of ethyl biscoumacetate and 200 to 300 mg. of bishydroxycoumarin are given at the same time by mouth; thereafter the bishydroxycoumarin is given daily in doses, generally of between 25 and 50 mg., that will maintain the prothrombin time between 22 and 35 seconds as determined by the Quick one-stage method. In some patients it is desirable to give heparin, 75 mg. subcutaneously at 12-hour intervals for two or three doses. The anticoagulant effect of the coumarin and indanedione compounds can be terminated promptly if necessary by the use of phytonadione (vitamin K1). It is frequently difficult to classify attacks of myocardial infarction as severe or mild during the early days of the attack. The decision as to which patients should receive any form of therapy must rest on the judgment of the physician.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();