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W. A. Altemeier, M.D.; Thomas Largen, M.D.
JAMA. 1952;150(15):1462-1468. doi:10.1001/jama.1952.03680150016005.
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The management of acute infections of the skeletal system has been greatly modified during the past decade by the use of antibacterial agents. These agents, which include those of nonbiologic origin, such as the sulfonamides, and those of biologic origin, such as the antibiotics, not only have radically changed our ideas concerning the most satisfactory methods of treatment in many instances but have also emphasized the extraordinary recuperative and regenerative powers of bone unimpeded by continuing infection. The intention of this discussion is to summarize the current knowledge of the use of various antibiotic and chemotherapeutic agents in the management of certain infections of the skeletal system, including acute osteomyelitis, acute purulent arthritis, chronic osteomyelitis, tuberculosis, syphilis, actinomycosis, and blastomycosis. Because of the increasing percentage in our environment of bacteria that are progressively developing resistance to the antibiotics, it is important to reappraise at frequent intervals the results obtained with


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