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ANTIBIOTIC AND CHEMOTHERAPEUTIC AGENTS IN INFECTIONS OF THE GENITOURINARY TRACT

Reed M. Nesbit, M.D.; W. C. Baum, M.D.
JAMA. 1952;150(15):1459-1462. doi:10.1001/jama.1952.03680150013004.
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The past two decades have witnessed advances in the development of antibacterial agents that have approached the goal that Ehrlich was seeking half a century ago. Today venereal disease has yielded so completely to antibacterial agents that successful treatment is dependent more on economic considerations than on professional skills. The response of urinary tract infections to the newer antibacterials has also been spectacular, but in this area the responsiveness to treatment has been less universal than that observed in specific genital infections. Effective, modern remedies bring about a quick response in urinary tract infections, with the result that the period of disability and suffering for many patients has been reduced. But today's physician, despite the many chemotherapeutic as well as antibiotic agents, continues to encounter a disturbing proportion of urinary infections that now, as in the past, fail to improve under therapy or recur following remission. These failures comprise a

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