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John Davis Hughes, M.D.
JAMA. 1952;150(15):1456-1459. doi:10.1001/jama.1952.03680150010003.
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The rational use of antibiotic and chemotherapeutic agents in intestinal infections, peritonitis, and preoperative preparation of the bowel has reduced morbidity and mortality in a spectacular manner.


Typhoid.  —The work of Woodward1 and others has shown that chloramphenicol (chloromycetin®) is the drug of choice in the treatment of typhoid. When this is used in adequate doses early in the disease and continued for at least 12 days the results are astonishing. Various methods of using the drug have been tried. A highly effective plan of therapy is as follows. The patient is given orally a loading dose of about 50 mg. per kilogram of body weight. For the average adult this represents about 4 gm. of the drug. Daily thereafter until the fever abates he should receive 4 gm. in divided doses at six hour or eight hour intervals. When the temperature has reached normal the dosage


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