We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |


Clyde B. Cope, M.D.; Paul Kassander, M.D.
JAMA. 1952;150(10):997-999. doi:10.1001/jama.1952.03680100039012.
Text Size: A A A
Published online


Ochronotic arthritis is a rare metabolic condition clinically characterized by a diagnostic triad1: (1) blue-black cartilages, especially of the ears and nose, brownish discoloration of the scleras, and gray-blue pigmentation of the skin; (2) urine that turns dark brown or black on standing or alkalinization; and (3) arthritis. There have been about 50 cases reported in the literature. Virchow,2 in 1866, described as postmortem findings the first case of ochronotic pigmentation and deforming arthritis. In 1904, Osler3 reported the first living patient with pigmented ears and scleras, rheumatic pains, Heberden's nodes, and nonglucose reducing substances in the urine. Because of the complexity and rarity of this clinical entity, none of the summaries in the literature can be considered complete or final. The most satisfactory reviews have been written by Oppenheimer and Kline4 and Smith.5

Hench6 has aptly stated that ochronotic arthritis resembles rheumatoid arthritis


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.