Carroll M. Leevy, M.C.
JAMA. 1956;161(3):270. doi:10.1001/jama.1956.02970030088026.
Text Size: A A A
Published online


To the Editor:—  The statement that the total circulating sodium is usually normal in uncomplicated sodium redistribution is based on studies using the techniques described. As expected from theoretical considerations, serial studies show some decrease in base line levels of total plasma sodium when there is a shift of sodium into tissue depots such as bone. However, except in patients with profound disturbances in acid-base and potassium balance (where other mechanisms are invoked), in our experience, cation shifts of less than 10% do not greatly alter the total circulating sodium, and resulting values fall within the range of our reported normal levels (370 to 470 mEq. in a 70-kg. man). Justification for estimating the total circulating sodium as described is that this type of study is available in most hospitals; it is easily and quickly obtained and can be repeated serially; resulting data reduce errors made when treatment is directed


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.