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John K. Lattimer, M.D.
JAMA. 1952;150(10):981-983. doi:10.1001/jama.1952.03680100023007.
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Early in 1952 the newspapers reported a new "wonder drug" for tuberculosis. The name of this drug is isoniazid (isonicotinic acid hydrazide). It is at least 600 times more powerful than p-aminosalicylic acid and appears more powerful than streptomycin in killing tubercle bacilli, at least in the test tube. Whether it will be as effective in vivo remains to be seen. Isoniazid does have a place in the treatment of renal tuberculosis. Like streptomycin, it brings about a gradual improvement in the cystoscopic appearance of the lesions of tuberculous cystitis and makes the urine culture sterile for tubercle bacilli in most patients. It is an excellent drug for the treatment of streptomycin-resistant patients. It is not toxic for the nephrons. One patient, who is living on only two renal pyramids, has shown a fall of the blood urea nitrogen level from 100 mg. per 100 cc. down to 25


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