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Nils R. Keiding, M.D.; Howard F. Root, M.D.; Alexander Marble, M.D.
JAMA. 1952;150(10):964-969. doi:10.1001/jama.1952.03680100006003.
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In the treatment of diabetes today the physician is faced with these questions: Does careful control pay? Is it necessary or worthwhile to attempt to establish physiological conditions as far as is possible, or will late vascular and nervous system complications appear despite the type of treatment, if diabetes is of sufficiently long duration? For the sake of providing easy treatment with a minimum of emotional disturbance to the patient, should one allow a "free diet" and disregard hyperglycemia and glycosuria as long as frank acidosis is not present? Such queries are basic both from a physiological and practical point of view and obviously deserve clearcut and unbiased answers, if these can be found. We have long been interested in this problem and during the last several years have carried out and reported on studies in this field.1 Wilson, Root, and Marble2 reported results of a study in


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