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ARTICLE |

THERAPEUTIC ASSAY OF TOPICALLY APPLIED PREDNISOLONE ALCOHOL IN SELECTED DERMATOSES

Erwin H. Zimmerman, M.D.
JAMA. 1956;162(15):1379-1381. doi:10.1001/jama.1956.72970320001008.
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Prednisolone alcohol (Meticortelone) is a synthetic crystalline steroid with the following structural formula:

Its structure differs from that of hydrocortisone free alcohol by the presence of a double bond between C1 and C2. In a recent study of the effects of orally administered prednisolone, Bunim, Pechet, and Bollet1 reported prednisolone to be approximately two to three times as effective as hydrocortisone as an anti-arthritic and anti-inflammatory agent, yet its use was unaccompanied by an increase in the severity of undesirable side-effects. Goldman, Flatt, and Baskett2 similarly found prednisolone to be more effective than hydrocortisone when administered orally in various dermatoses. Their studies indicated that prednisolone was four to five times as effective, dosage for dosage, as hydrocortisone. Since both hydrocortisone acetate and hydrocortisone free alcohol have been reported to be of value in the topical therapy of various dermatoses and to be of equal therapeutic value

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