We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |


Robert E. L. Nesbitt Jr., M.D.; C. Bernard Brack, M.D.
JAMA. 1956;161(3):183-188. doi:10.1001/jama.1956.02970030001001.
Text Size: A A A
Published online


• The accuracy of diagnostic tests for carcinoma of the cervix was studied in a series of 5,617 women in whom cancer had not been previously diagnosed or treated. Each patient, in addition to a gynecologic history, abdominal and pelvic examinations, and cervical palpation and inspection, had multiple punch biopsies and cervical and vaginal smears.

Of the 310 proved cases of cervical cancer in this series, 222 were correctly diagnosed by the initial smear. Analysis of the data for false-positive, false-negative, and dubious or conflicting reports leads to the conclusion that the greatest value of the cervical smear lies in the detection of early cervical lesions and that it should be used as a screening technique for the detection of lesions in the grossly unremarkable cervix.

The cervical smear and biopsy are complementary adjuncts in the detection of cancer. Definitive diagnosis is never justified on the basis of one smear. Multiple biopsies are frequently necessary for complete clinical evaluation of the case before instituting definitive therapy.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.