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Agnus Therese Simpler, M.D.; Maria Corazon Jaramillo, M.D.; Gilmary Simmons, M.D.
JAMA. 1956;162(9):881-882. doi:10.1001/jama.1956.02970260031009.
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• Salmonellosis in 86 patients was treated with chloramphenicol and typhoid-paratyphoid vaccine. The chloramphenicol caused the temperature to return to normal generally within four days. The frequency of recurrences depended on the amount of vaccine given. The ratios for recurrence were 1:4 (i. e., 4 out of 16) for patients treated without vaccine, 1:7 in 29 patients treated with less than 1.5 cc. of vaccine, and 1:20 in 41 patients treated with more than 1.5 cc. of vaccine. The combined therapy appeared to be a promising means of reducing the danger of recurrence.


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