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JAMA. 1952;150(5):506-507. doi:10.1001/jama.1952.03680050072024.
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Electroencephalograms, Corticotropin, and Cortisone.  —At the Hospital for Sick Children, Prof. R. Debré, Dr. P. Mozziconacci, and Dr. J. Nekhorocheff studied the electroencephalograms of 74 children treated with corticotropin and cortisone and observed alteration in 38 of them. In 17 of these, alterations consisted in slow waves on the encephalogram of rest; 17 others showed positive reactions to intermittent luminous stimulation. Of 34 patients with Bouillaud's syndrome, 18 had at least one abnormal electroencephalogram; and of 18 patients with reticulosis and leukosis, 12 had abnormal electroencephalograms. The possible coincidence of constitutional electrical alterations and of modifications to the diagram owing to the disease itself (anemia of nervous centers and cerebral edema) has to be taken into account to arrive at a correct estimation of the results obtained. Nevertheless, in 20 cases the altered diagrams remained attributable to the hormonal treatment; according to the authors, cortisone provoked electrical alterations more frequently


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