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JAMA. 1952;150(5):505. doi:10.1001/jama.1952.03680050071022.
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Italian Society of Endocrinology.  —The Italian Society of Endocrinology met in Pisa under the chairmanship of Professor Pende, from the University of Rome, Professor Cassano, from the University of Pisa, and Professor Antonietti, from the University of Genoa. Numerous clinicians and endocrinologists from northern and central Italy were present.Professors N. Pende and V. Pende, from the University of Rome Institute of Medical Pathology, reported on five patients who had infantile myxedema with generalized muscle hypertrophy and strength comparable to that of a strong adult. After therapy with thyroid and anterior hypophysis extracts, the mental and physical development improved and the myxedematous facies became normal, but muscle hypertrophy and hyperergy persisted. Two patients had hypercreatinemia, which is not usually seen in states of hypothyreosis. The speakers advanced the hypothesis that the excess muscle anabolism may cause, in congenital and adult hypothyreosis, muscle hypertrophy with hypertonia and increased contractile energy. The


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