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H. Clinton Davis, M.D.; Irwin S. Morse, M.D.; Edward Larson, Ph.D.; Mark Wynn, M.S.
JAMA. 1956;162(6):561-563. doi:10.1001/jama.1956.72970230003009a.
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The usual liver-function studies coupled with needle biopsy of the liver have been valuable in appraising liver disease. They permit an accurate appraisal of the pathology without an exploratory operation, and frequently they avert an unnecessary surgical procedure. Yet, the occasional poor correlation between the laboratory and pathological reports serves as a constant stimulus to develop new methods of research or to reapply older techniques for further biological information. Direct physiological tests on liver tissue have been used for many years in experimental work on small animals; however, relatively little work has been done on the respiratory metabolism of the human liver. The frequency with which liver biopsy specimens are taken at the operating table for pathological examination, and the benignity of the procedure, have prompted us to send a portion of our specimens to both the pathologist and the physiologist.1 To our knowledge, at the start of this


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