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ARTICLE |

SYMMETRICAL CEREBRAL CALCIFICATION ASSOCIATED WITH PARATHYROID ADENOMA

Warren P. Knuth, M.D.; Paul Kisner, M.D.
JAMA. 1956;162(5):462-464. doi:10.1001/jama.1956.72970220004006b.
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The presence of symmetrical cerebral calcification, particularly in the region of the basal ganglions, has been reported in connection with a wide variety of different disease entities. This subject was investigated and the literature extensively reviewed by Eaton, Camp, and Love in 1936. They added an additional six cases to the literature, the condition in all of which was diagnosed ante mortem by means of skull roentgenograms. They noted that parathyroid insufficiency was frequently seen to accompany this condition. They emphasized that roentgenograms should be taken of the skulls of all patients with hypoparathyroid tetany. Subsequent reports have confirmed the original impression of Eaton and his co-workers,1 and, in 1947, Camp2 reported a series of 12 cases in which the patients had roentgenographically demonstrable symmetric cerebral calcification and parathyroid insufficiency. However, inasmuch as there has been no instance of hyperparathyroidism or parathyroid adenoma in any of these reported

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