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James B. Dibble, M.D.; Joseph Cascino, M.D.
JAMA. 1956;162(5):461-462. doi:10.1001/jama.1956.72970220003006a.
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The incidence of formation of tuberculous granulomas of the spinal cord is rare enough that we thought it worthwhile to report in detail a case we have recently observed. The first tuberculoma of the spinal cord was described in 1830 by Serre1 in France. During the following 105 years only 87 such cases have been described in the world literature.2 In reviewing the literature since 1935, we have been able to find only 84 more cases in the English-speaking literature.

The pathogenesis of tuberculoma of the spinal cord is now thought to be3: 1. A tubercle forms in the spinal cord or in the membranes, being blood-borne in the vast majority of instances. 2. This tubercle provokes a reactive phenomenon that causes proliferation of powerful connective tissue elements that form the granuloma. 3. Drainage persists into and by the subarachnoid space. 4. An inflammatory reaction occurs in


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