First Italian Convention on Cortisone.
—The Italian Society of Rheumatology sponsored the first Italian Convention on Cortisone, which was held in Taormina in June. Dr. Selirie, from New York, was present at the convention, during which reports were read by Professors Luigi Villa, Camillo Ballabio, and Gianni Sala, from the University of Milan.The speakers considered the problem of whether cortisone is the only and main hormone secreted by the adrenals, besides androgen hormones, and whether it participates in the activity of other hormones with definite and antagonistically balanced functions. From recent studies it appears that cortisone and compound A (11-dehydrocorticosterone) are the respective metabolites of the F and B compounds (17-hydroxycorticosterone and corticosterone). Consequently, the antagonism between mineral-active and glycoactive hormones, about which much has been written, is denied and the secretion of pure mineralocorticoids of the desoxycorticosterone acetate type is likewise denied. Cortisone does not cause significant changes