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ARTICLE |

INHIBITION OF TUBERCULIN REACTION BY LOCAL INJECTION OF COMPOUND F

Leon Goldman, M.D.; Robert H. Preston, M.D.; Evelyn Rockwell, M.D.; Jeanne Baskett, B.S.
JAMA. 1952;150(1):30-31. doi:10.1001/jama.1952.63680010003008b.
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In previous experiments it was shown that local injection of a suspension of compound F acetate in the skin inhibited the reaction of that area of skin to chemical compounds to which the skin was sensitive. These compounds were applied directly over the injection site.1 It has been found also that compound F is capable of inhibiting the reaction to insect bites over the injected area, even after four months.2 In many of these experiments, controls were done with cortisone and cholesterol suspended in the same type of vehicle. Our previous experiments with cortisone had not revealed any such local inhibition of skin reactions.3 Compound F has also been found to have a local effect when injected directly into a joint.4

In this series of experiments, studies were made of the local inhibition of tuberculin and tuberculin-like reactions by compound F acetate. Corticotropin (ACTH) or cortisone

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