0
ARTICLE |

HEPATITIS FOLLOWING THE INGESTION OF PHENYLBUTAZONE

Ephraim P. Engleman, M.D.; Marcus A. Krupp, M.D.; James F. Rinehart, M.D.; Robert C. Jones; John R. Gibson, (MC)
JAMA. 1954;156(2):98-101. doi:10.1001/jama.1954.02950020004002.
Text Size: A A A
Published online

Many of the toxic reactions to phenylbutazone have been reported previously; these have included edema1 and toxic effects on the skin,2 gastrointestinal tract,3 hematopoietic system,4 central nervous system,2a heart,5 and probably the eye.5a The possibility of deleterious effects of phenylbutazone on the liver has not been publicized adequately. The following case reports illustrate the potential severity of such complications.

REPORT OF CASES 

Case 1.—  A 78-year-old white housewife was hospitalized on Nov. 28, 1952, because of jaundice of four days' duration. For some 40 years she had complained of multiple joint pains, which were caused by degenerative joint disease, especially of the hips. On Oct. 16, 1952, phenylbutazone therapy was started in a daily oral dose of 800 mg. Symptomatic improvement was noted. On or about Nov. 1 she experienced mild abdominal pain, which persisted until her entry into the hospital. On Nov.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();