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Richard Charet, M.D.; Irving Siegel, M.D.
JAMA. 1953;151(7):556-557. doi:10.1001/jama.1953.02940070022007a.
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Phenylbutazone (butazolidin®) is a drug widely used for relief of arthritis and allied disorders. It was first synthesized in 1948 and has received extensive clinical trial. Its pharmacology was investigated by Wilhelmi, who showed that in laboratory animals it acted as a mild analgesic, a moderately powerful antihistaminic, an antiphlogistic, and an antipyretic. The drug is used chiefly by the oral route. The reported incidence of undesirable side reactions has varied from 25 to 33%, while in about 12% of cases the toxic manifestations made it necessary to discontinue the use of the drug. Toxic reactions described have been edema, nausea and abdominal discomfort, reactivation of latent peptic ulcer, anemia, vertigo, and skin eruptions.


A 44-year-old white man was admitted to Prospect Heights Hospital on Sept. 5, 1952, with a history of chills, fever, malaise, sore throat, dysphagia, photophobia, blepharospasm, and a generalized eruption for two days.


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